Validation studies for quantitative analytical methods

Validation studies for quantitative analytical methods typically determine some or all of the following parameters:


The principal precision measures include repeatability standard deviation sr, reproducibility standard deviation sR, (ISO 3534-1) and intermediate precision


The bias of an analytical method is usually determined by study of relevant reference materials or by spiking studies.


Linearity is an important property of methods used to make measurements at a range of concentrations.

Detection Limit

The detection limit is normally determined only to establish the lower end of the practical operating range of a method.

Robustness or ruggedness

the effect of one or more parameter changes is observed


Typical selectivity studies investigate the effects of likely interferents, usually by adding the potential interferent to both blank and fortified samples and observing the response.


EURACHEM / CITAC Guide CG 4. Quantifying Uncertainty in Analytical Measurement Second Edition.

Tinggalkan Balasan

Isikan data di bawah atau klik salah satu ikon untuk log in:


You are commenting using your account. Logout /  Ubah )

Foto Google

You are commenting using your Google account. Logout /  Ubah )

Gambar Twitter

You are commenting using your Twitter account. Logout /  Ubah )

Foto Facebook

You are commenting using your Facebook account. Logout /  Ubah )

Connecting to %s